Although signaling cascades mediating alveolar bone remodeling in response to the orthodontic force have been the center of interest in dental research, it is still not clearly understood the molecular mechanisms underlying mechanical force-induced alveolar bone remodeling and orthodontic tooth movement. This presentation will provide clues for the enigmatic linkage between orthodontic force and alveolar bone remodeling by demonstrating the role of sensory nerves and mechanosensitive ion channel Piezo2 in initiating orthodontic tooth movement.
Learning Objectives:
After this session, attendees will be able to:
Demonstrate that the ablation of TRPV1+ trigeminal afferents reduces orthodontic tooth movement, supporting the 'no pain, no gain' concept.
Identify the contribution of Mechanosensitive Ion Channel Piezo 2 in initiating orthodontic tooth movement.
