Oral immune responses reflect local host-pathogen dynamics at the site of SARS-CoV-2 infection. We leveraged multiplex technology to analyze saliva collected from 227 SARS-CoV-2+ participants and 37 uninfected controls. We demonstrate that the salivary immune landscape is dramatically altered in early SARS-CoV-2+ infection with significant differential expression of 25 cytokines and marked natural killer and adaptive (T and B cell) immune suppression. Our work highlights the public health potential of salivary biomarker monitoring for COVID-19 diagnosis, prognosis, and vaccine or treatment response.
Learning Objectives:
After this session, attendees will be able to:
Discuss immune pathways altered in the presence of SARS-CoV-2.
Identify specific mediators involved in orthodontic tooth movement that are dysregulated by SARS-CoV-2.
Illustrate the role of saliva as a biomarker for disease diagnosis and prognosis.
