External root resorption is a silent condition characterized by the progressive loss of cementum and/or dentin through the action of osteoclast-like cells. Currently, radiography and cone-beam computed tomography (CBCT) have been the standard techniques used by orthodontists to monitor root resorption. Nevertheless, the orthodontic population undergoes limited screening due to radiation risks. In addition, imaging methods are not able to discern if the process of root resorption is ongoing or historical. With no curative treatment available and the risk of potential tooth loss, the search for a “liquid biopsy” screening method for early diagnosis of tooth resorption is of key interest to the orthodontic field and others alike. The goal of this presentation is twofold: 1) Review clinical cases and discuss patient management in the presence of root resorption, and 2) Discuss the findings of a recent study carried out by our group and funded by the NIH-NIDCR (R03DE027504) which sought to use novel technologies to identify potential biomarkers for this condition.
Learning Objectives:
After this session, attendees will be able to:
Review best practices to prevent root resorption in the clinical setting.
Understand ongoing research efforts to identify novel biomarkers with promising benefits for diagnosis of dental root resorption.
Describe the biological principles underlying dental root resorption.
